Severe multiple trauma, Inflammatory cytokine storm,MODS
Conditions
Interventions
Observation group:NA
Sponsors
Peking University People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Samples from patients with severe polytrauma, an Injury Severity Score (ISS) >15, and who received treatment within 24 hours of injury. 2.Aged >=18 years, both male and female are eligible.
Exclusion criteria
Exclusion criteria: 1.Patients with a definitive diagnosis of open injuries at extremely high risk of infection (beyond Gustilo Type IIIA), hollow viscus injuries, or severe traumatic brain injury (TBI with AIS >= 3). 2.Having a confirmed source of infection or suffering from infectious diseases; at high risk of infection. 3.Women who are pregnant or breastfeeding. 4.Females aged 18-50 who are confirmed to be pregnant upon testing. 5.Severe primary diseases that affect survival (such as inoperable tumors, hematologic diseases, acute exacerbation of cardiovascular and cerebrovascular diseases and respiratory diseases, HIV, etc.). 6.Use of immunosuppressive agents within the past 6 months (total cumulative dose of glucocorticoids, converted to methylprednisolone, =1500 mg, and/or use of cytotoxic drugs), or use of either of the above two categories of drugs within the past 7 days. 7.Patients with psychiatric disorders. 8.Participants who have taken part in other clinical trials within the past 30 days. 9.Individuals whom the investigator deems unable or unsuitable to complete the study. 10.Patients with residual serum sample volume < 0.5 mL.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cytokines: IL-18, IP-10, MCP-1, Eotaxin, MCP-4, CXCL12, MIP-3a, IL-1RA, Cystatin C, MRP8/14; | — |
Countries
China
Contacts
Public ContactTianbing Wang
Peking University People's Hospital
Outcome results
None listed