lung cancer
Conditions
Interventions
experimental group:Individualized PEEP titration is adopted for PEEP during mechanical ventilation
control group:When performing mechanical ventilation, a fixed PEEP of 5 is adopted
Sponsors
Shanghai Chest Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Lung cancer patients scheduled for elective general anesthesia thoracoscopic or open surgical lung resection; 2. ARISCAT score >=45 ; 3. During the operation, lung isolation is required and single-lung ventilation should be implemented; 4. The patient should be hospitalized for at least 2 days after the operation; 5. American Society of Anesthesiologists (ASA) Health Classification II -III.
Exclusion criteria
Exclusion criteria: 1. Obesity, BMI> 35; 2. There were moderate symptoms of dyspnea before the operation, PaO2/FiO2<200mmHg ; 3. Preoperative heart failure: NYHA grade greater than or equal to grade IV; 4. Preoperative hemodynamic instability, CI < 2.5 L/min/m2 and/or positive inotropic drugs are required for support; 5. There has been mechanical ventilation in the past 15 days; 6. Those who had pneumothorax before the operation or showed pulmonary bullae on imaging examinations; 7. Those who have bronchiectasis, respiratory tract infection, persistent cough with expectoration and excessive secretions in the lungs before the operation; 8. CPAP breathing assistance is required before the operation; 9. Participate in other clinical trials; 10. Those who are expected to be intolerant to PEEP titration (those expected to experience hypotension or hypoxia during the titration process); 11. Any conditions that are not suitable for EIT measurement (pacemakers, automated implantable defibrillators, implant pumps).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of pulmonary complications during postoperative hospitalization; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative hospital stay;Other complications during hospitalization;driving pressure;lung compliance;Arterial blood oxygenation index;mean arterial pressure;Complications from discharge to 30 days after the operation;Incidence of hypoxemia;extubation time; | — |
Countries
China
Contacts
Public ContactJingxiang Wu
Shanghai Chest Hospital
Outcome results
None listed