Postoperative fatigue syndrome (POFS) occurs in the recovery period of patients after surgery, mainly manifested as varying degrees of distraction, physical weakness, lack of subjective initiative, etc. Clinical symptoms are often exhaustion, muscle fatigue, body pain, physical exhaustion, gastrointestinal dysfunction and abnormal sleep.
Conditions
Interventions
Group Ciprofol Injection:Using Cyclopholol intravenously for general anesthesia
Group Remimazolam:Using Cyclopholol intravenously for general anesthesia
Sponsors
Hefei First People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Lumbar surgery; 2.General anesthesia; 3.ASA Grade I-II; 4.18.5kg/m^2<BMI<30kg/m^2.
Exclusion criteria
Exclusion criteria: 1.Patients with severe neurological disease resulting in limited limb movement; 2.Patients with Severe pulmonary hypertension, heart failure, liver and kidney insufficiency decompensated; 3.Persons with mental abnormalities or mental illness; 4.Persons Those allergic to clofibrate and remazolam; 5.Persons with severe hypotonia and central nervous system diseases before surgery; 6.Patients who had received other treatment in the last 6 months (at time of consent); 7.Patients who are judged to be lacking capacity for consent; 8.Patients who have recently taken analgesic and sedative drugs; 9.Patients judged by the attending physician or the attending physician in charge of the clinical department as inappropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Christensen Fatigue Rating Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Levels of inflammatory factors: interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a) and C-reactive protein (CRP);Upper limb grip strength;VAS score;Time to get out of bed for the first time; | — |
Countries
China
Contacts
Public ContactZhang Jing
Hefei First People's Hospital
Outcome results
None listed