Depression
Conditions
Interventions
Sertraline Group:None
Fluoxetine Group:None
Healthy Control Group:None
Sponsors
The Fourth People's Hospital of Ya'an City
Eligibility
Sex/Gender
All
Age
11 Years to 17 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria for Depressive Participants (1) Aged 11–17 years, regardless of gender; (2) Meeting the diagnostic criteria for "depression"-related disorders as defined in the International Classification of Diseases, 10th Revision (ICD-10); (3) First-visit patients; (4) No tendency of self-harm. Inclusion Criteria for Healthy Participants (1) Aged 11–17 years, regardless of gender; (2) Individuals who do not meet the diagnostic criteria for any psychiatric disorder, based on anxiety/depression scale scores and clinical interview findings.
Exclusion criteria
Exclusion criteria: Exclusion Criteria for Depressive Participants (1) Having taken antibiotics, probiotics, or other medications within 1 month prior to treatment; (2) Having experienced primary gastrointestinal diseases or severe diarrhea within 1 month prior to treatment; (3) Having failed to take medication continuously as prescribed or with poor medication adherence; (4) Participants receiving combined drug therapy; (5) Participants with organic depressive disorder or accompanied by other somatic or psychiatric symptoms; (6) Involuntary participants or those who have resistance to any aspect of the study process; (7) Having a history of pregnancy, drug abuse, alcoholism, or similar experiences. Exclusion Criteria for Healthy Participants (1) Having taken antibiotics, probiotics, or other medications within 1 month prior to enrollment; (2) Having experienced primary gastrointestinal diseases or severe diarrhea within 1 month prior to enrollment; (3) Involuntary participants or those who have resistance to any aspect of the study process; (4) Having a family history of psychiatric disorders or a personal history of pregnancy, drug abuse, alcoholism, or similar experiences.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gut microbial diversity;gut microbial abundance;Children, Depression Inventory,CDI; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Screen for Child Anxiety Related Emotional Disorders,SCARED; | — |
Countries
China
Contacts
Public ContactHe Lei
The Fourth People's Hospital of Ya'an City
Outcome results
None listed