Premature Ovarian Insufficiency,Premature Ovarian Failure
Conditions
Interventions
Healthy control group:NA
POI/POF group:NA
Sponsors
The International Peace Maternity and Child Health Hospital
Eligibility
Sex/Gender
Female
Age
12 Years to 39 Years
Inclusion criteria
Inclusion criteria: 1. POI (Premature Ovarian Insufficiency) is diagnosed in women under 40 years of age who present with oligomenorrhea, hypomenorrhea, amenorrhea, or infertility, and have two consecutive baseline serum FSH levels >25 IU/L and <40 IU/L. 2. POF (Premature Ovarian Failure) is diagnosed in women under 40 years of age who experience menopause, accompanied by perimenopausal symptoms (such as hot flashes, night sweats, irritability, palpitations, insomnia, chest tightness, headaches, memory loss, lumbar and leg soreness, etc.), and have two consecutive baseline serum FSH levels =40 IU/L. 3. Tthe karyotype analysis must indicate a normal female karyotype, 46, 4. Testing for the FMR1 gene premutation (through assessment of FMRP, fragile X mental retardation protein) must yield negative results.
Exclusion criteria
Exclusion criteria: 1. Age over 40 years; 2. Post-chemotherapy for malignant tumors; 3. Patients with genetic factors or comorbid autoimmune diseases (e.g., hyperthyroidism, hypothyroidism, systemic lupus erythematosus); 4. Surgical factors (e.g., bilateral oophorectomy); 5. Patients with severe primary diseases of the cardiovascular, cerebrovascular, hepatic, renal, or hematopoietic systems, or psychiatric disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Methylation detection; | — |
Secondary
| Measure | Time frame |
|---|---|
| Metabolic Markers;Chronic Stress Score; | — |
Countries
China
Contacts
Public ContactDongmei Lai
The International Peace Maternity and Child Health Hospital
Outcome results
None listed