Adolescent MDD
Conditions
Interventions
real group:real TIs group
sham group:sham TIs group
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1.Age: 12-18 years old; 2.Meet the MDD diagnostic criteria for DSM-V; 3.The score of HAMD-17>=17; 4.Right-handed; 5.Physical examination, medical history, vital signs, routine blood, urine and stool tests, liver and kidney function, electrolytes, electrocardiogram, electroencephalogram and other indicators are all normal; 6.After fully understanding the safety of transcranial electrical stimulation, I am willing to actively cooperate with the treatment and have both myself and my family sign informed consent;
Exclusion criteria
Exclusion criteria: 1.Other physical therapies, such as electroconvulsive shock, transcranial magnetic stimulation, transcranial electrical stimulation, etc., were received within 3 months before enrollment; 2.Those with a history of severe physical illness and depression caused by other psychoactive substances and non-dependent substances; 3.Subjects who have metal or electronic devices implanted in their bodies, such as intracranial metal foreign bodies, cochlear implants, pacemakers and stents, etc; 4.There is a risk of epileptic seizures, with a history of craniocerebral diseases, head trauma, alcohol abuse, abnormal electroencephalograms, MRI evidence of abnormal brain structure, or a family history of epilepsy; 5.There has been a history of attempted suicide in the past two weeks; 6.The types of drugs have remained unchanged and the dosages have been stable in the past two weeks;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of 17-item Hamilton Depression Rating Scale (HAMD-17) scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Multimodal neuroimaging features, including structural and functional magnetic resonance imaging (MRI), functional near-infrared spectroscopy (fNIRS), transcranial magnetic stimulation-evoked motor po;Adverse Event Scale;Clinical symptom changes were assessed using standardized clinical rating scales;Changes in relevant indicators related to cognition based on scales and computer behavior tasks; | — |
Countries
China
Contacts
Public ContactXiaoli Liu
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed