Valvular heart disease
Conditions
Interventions
Test group:A precise multimodal analgesia protocol
Sponsors
Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Elective surgery; 2. Patients undergoing median sternotomy for valve replacement or repair; 3. Adults aged between 18 and 64 years inclusive; 4. New York Heart Association (NYHA) functional class II–III.
Exclusion criteria
Exclusion criteria: 1. Patients unable to communicate or be reliably assessed due to language barriers, hearing impairment, psychiatric disorders, or similar conditions; 2. Patients with severe hepatic or renal insufficiency; 3. Patients with a history of substance dependence or abuse; 4. Patients diagnosed with diabetes mellitus and concomitant peripheral neuropathy; 5. Patients with known hypersensitivity or contraindications to the study medication; 6. Patients with contraindications to paravertebral block, including infection or coagulopathy at the injection site; 7. Pregnant or breastfeeding women; 8. Patients reporting preoperative chronic pain in the anterior chest wall; 9. Patients with second- or third-degree atrioventricular block or sinus node dysfunction without an implanted pacemaker; 10. Patients or their legally authorized representatives who decline to provide informed consent; 11. Individuals deemed unsuitable for enrollment by the principal investigator based on clinical judgment.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Indicators of acute perioperative pain;perioperative hemodynamic parameters;markers of rapid recovery;perioperative adverse events; | — |
Primary
| Measure | Time frame |
|---|---|
| Postoperative chronic pain; | — |
Countries
China
Contacts
Public ContactYe Zhi
Xiangya Hospital, Central South University
Outcome results
None listed