Heart disease
Conditions
Interventions
Experimental group (sivelestat sodium group):After induction of anesthesia, sivelestat sodium was continuously pumped intravenously (total amount 4.8 mg/kg mixed with 48ml) at a pumping rate of 1.2 mg
Control group (normal saline group):In the control group, the same volume of normal saline (48 ml) was continuously pumped intravenously after anesthesia induction, and the pumping speed was 12 ml/h u
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective CPB open heart surgery; 2. Preoperative echocardiography estimates pulmonary artery pressure>25mmHg; 3. ASA classification II-IV; 4. Age >= 18 years old, regardless of gender; 5. NYHA classification II-IV; 6. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Individuals who are allergic or contraindicated to Sivirastat sodium and its drug components; 2. Severe heart failure, ASA level V or above; 3. Abnormal liver function: ALT and/or AST exceeding 1.5 times the upper limit of the medical reference range; 4. Abnormal renal function: those whose creatinine exceeds the upper limit of the medical reference range; 5. Patients undergoing secondary surgery; 6. Long term use of immunosuppressants or acquired immunodeficiency syndrome before surgery; 7. Pregnant and lactating women; 8. Patients who refuse to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes of oxygenation index at 24 hours after operation and oxygenation index before anesthesia induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ventilation machine usage time;Duration of stay in intensive care unit;Postoperative hospitalization time;Postoperative extubation time; | — |
Countries
China
Contacts
Public ContactLifang Zhou
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed