Breast Cancer
Conditions
Interventions
Trial Group:Following tracheal extubation, intravenous patient-controlled analgesia (PCA) with oliceridine fumarate was initiated for postoperative pain management after PCI. The PCA solution containe
Control Group:Following tracheal extubation, intravenous patient-controlled analgesia (PCA) with sufentanil was initiated for postoperative pain management after PCI. The PCA solution contained 2 µg/k
Sponsors
Shenzhen Nanshan District People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. 18 years 2 hours; 3. BI-RADS category 4; 4. Voluntary participation with signed informed consent; 5. ASA classification I–II;
Exclusion criteria
Exclusion criteria: 1. History of solid organ or bone marrow transplantation; 2. Diseases that may affect immune-related indicators, such as autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) or malignant hematologic tumors (e.g., leukemia, lymphoma); 3. History of radiotherapy or chemotherapy; 4. Intraoperative blood transfusion; 5. Acute myocardial infarction or severe heart failure (NYHA Class IV); 6. Severe chronic liver disease (Child-Pugh Class C); 7. Chronic kidney disease; 8. Pregnancy or lactation; 9. Acute brain injury (traumatic brain injury, subarachnoid hemorrhage, acute ischemic stroke, acute intracranial hemorrhage, acute intracranial infection); 10. Deafness, aphasia, psychiatric disorders, or severe cognitive impairment; 11. Delayed awakening; failure to extubate within 24 hours postoperatively; direct admission to ICU postoperatively; 12. Intraoperative pathology confirming a benign tumor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ratio of lymphocyte subsets CD4+ and CD8+ cells in the patient's blood 24 hours after surgery.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cytokines (IL-10, IL-1a, and IL-6) in the patient's blood.;VAS scores during rest and exercise;Adverse reactions;Patient satisfaction scores; | — |
Countries
China
Contacts
Public ContactWei Hong
Nanshan People's Hospital, Shenzhen
Outcome results
None listed