obsessive-compulsive disorde
Conditions
Interventions
Healthy Control Group:Temporal interference stimulation
Adolescent Obsessive-Compulsive Disorder Group:Temporal Interference Stimulation: active stimulation
Adolescent Obsessive-Compulsive Disorder Group:Temporal Interference Stimulation: sham stimulation
Sponsors
Shandong Daizhuang Hospital
Eligibility
Sex/Gender
All
Age
10 Years to 50 Years
Inclusion criteria
Inclusion criteria: Study 1: Healthy Participants: (1) aged 10–50 years; (2) voluntary participation with informed consent obtained from both participants and their guardians; (3) ability to comprehend written language and complete questionnaires; (4) normal or corrected-to-normal vision; (5) of Han ethnicity and right-handed. Study 2: Adolescent Patients with Obsessive-Compulsive Disorder: (1) met DSM-5 diagnostic criteria for OCD as confirmed by the Structured Clinical Interview for DSM-V (SCID-V); (2) aged 10–18 years; (3) voluntary participation with informed consent obtained from both patients and their guardians; (4) ability to comprehend written language and complete questionnaires; (5) normal or corrected-to-normal vision; (6) of Han ethnicity and right-handed.
Exclusion criteria
Exclusion criteria: Study 1: Healthy Participants: Exclusion criteria included: (1) history of substance dependence; any current or past mental disorder meeting diagnostic criteria for SCID Axis I or II disorders; history of traumatic brain injury, epilepsy, or other organic brain diseases; (2) previous history of loss of consciousness; (3) positive family history of psychiatric disorders within three generations across both parental lines; (4) previous use of antipsychotic or antidepressant medications; continuous pharmacotherapy within the past 6 months; (5) inability to cooperate with or effectively complete the assessment; (6) abnormal laboratory tests indicating impaired liver or kidney function, or other serious systemic or metabolic disorders; (7) contraindications for MRI; (8) contraindications for TIS, including intracranial implants (e.g., aneurysm clips, shunts, stimulators, cochlear implants, or electrodes); any metallic objects in or near the head that cannot be safely removed; use of medications that may interfere with TIS efficacy, such as barbiturates, benzodiazepines, and certain anticonvulsants; (9) pregnancy or lactation; (10) color blindness. Study 2: Adolescent Patients with Obsessive-Compulsive Disorder (OCD): Exclusion criteria included: (1) history of substance dependence; any mental disorder other than depression or anxiety meeting SCID Axis I or II diagnostic criteria; history of traumatic brain injury, epilepsy, or other organic brain diseases; (2) inability to cooperate with or effectively complete the assessment; (3) abnormal laboratory tests indicating impaired liver or kidney function, or other serious systemic or metabolic disorders; (4) contraindications for MRI; (5) contraindications for TIS, including intracranial implants (e.g., aneurysm clips, shunts, stimulators, cochlear implants, or electrodes); any metallic objects in or near the head that cannot be safely removed; use of medications that may interfere with TIS efficacy, such as barbiturates, benzodiazepines, and certain anticonvulsants; (6) pregnancy or lactation; (7) color blindness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Multimodal time-series analysis of resting-state fMRI (rs-fMRI) will be employed to examine the immediate modulatory effects of nucleus accumbens (NAcc)-targeted temporal interference stimulation (TIS) on the reward network;Combining behavioral science, time-frequency domain electroencephalogram (EEG) and event-related potential (ERP) techniques, a systematic assessment of the impact of temporal interference stimulation (TIS) on reward processing and cognitive control was conducted.; | — |
Countries
China
Contacts
Public ContactKun Li
Shandong Daizhuang Hospital
Outcome results
None listed