Gastroesophageal reflux disease (GERD),Cardiovascular diseases requiring dual antiplatelet therapy
Conditions
Interventions
Acid-suppressing drug treatment group:None
Sponsors
The Seventh Affiliated Hospital Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Patients with newly diagnosed gastroesophageal reflux disease (GERD), confirmed by clinical evaluation. 2.Local residents who can comply with the study follow-up requirements. 3.Individuals who voluntarily agree to participate in the study after being fully informed and providing written informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients who have used medications that could significantly affect the gut microbiota within the past three months, including antibiotics and metformin. 2.Patients with active malignancies or major cardiovascular or cerebrovascular diseases. 3.Pregnant or breastfeeding women. 4.Other conditions determined by the clinical investigator that might interfere with the study outcomes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum diamine oxidase;Lipopolysaccharide Binding Protein;Changes in multi-omics parameters;Change in cytokines;Streptococcus salivarius;Faecal Lactoferrin;Faecal zonulin;Changes in anthropometric indicators;Faecal calprotectin;Veillonella parvula; | — |
Countries
China
Contacts
Public ContactBin Xia
The Seventh Affiliated Hospital Sun Yat-sen University
Outcome results
None listed