Trauma bleeding and surgical bleeding
Conditions
Interventions
LTOWB group:Transfusion was initiated in accordance with the transfusion indications outlined in WS/T 623—2018: Guidelines for the Use of Whole Blood and Blood Components. The initial transfusion cons
Component blood group:Red blood cells, plasma, and platelets were transfused in accordance with the transfusion indications specified in WS/T 623—2018: Guidelines for the Use of Whole Blood and Blood
Sponsors
The First Medical Center of the Chinese People's Liberation Army General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Adult patients: aged 18 to 70 years old (inclusive of 18 and 70 years old), regardless of gender, with blood types A, B, or AB and RhD positive. 2.Have received at least 2U of LTOWB or red blood cells. 3.Patients undergoing elective surgeries that require a large amount of blood reservation. 4.Traumatic bleeding patients who are expected to receive a large - volume blood transfusion. 5.Requirements for the type of surgery: patients planning to undergo liver surgery, orthopedic surgery. 6.Be capable of signing the informed consent form for the study.
Exclusion criteria
Exclusion criteria: 1.History of transfusion reactions or severe allergies. 2.Preoperative use of anticoagulants, antiplatelet agents, or other drugs that may affect coagulation function. 3.Presence of red blood cell antibodies. 4.Combined immunodeficiency or autoimmune diseases. 5.Combined end-stage liver disease or renal failure. 6.Active infectious diseases or hematologic malignancies. 7.Subject or family members refuse to participate in the study. 8. Participation in any other clinical trial within 4 weeks prior to the start of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Transfusion reaction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Red blood cell transfusion volume;Total blood transfusion volume;Blood loss;TEG;Coagulation function;Blood routine;Biochemistry;Direct antiglobulin test;Blood type;Irregular antibody;Blood transfusion time;Intensive Care Unit Time;Hospitalization period; | — |
Countries
China
Contacts
Public ContactYu yang
Department of Transfusion Medicine, The First Medical Center of Chinese PLA General Hospital
Outcome results
None listed