Primary central nervous system lymphoma
Conditions
Interventions
Case group:None
Sponsors
Affiliated Cancer Hospital of Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18-70 years, male or female, with an expected survival of more than 3 months; 2. Patients with untreated, pathologically or cytologically confirmed primary central diffuse large B-cell lymphoma; 3. Patients with adequate organ function, including: Blood routine: ANC >=1.5×10^9/L, Hb >=80g/L, PLT>=75×10^9/L; Liver function abnormalities (total bilirubin 50ml/min.
Exclusion criteria
Exclusion criteria: 1. Contraindications for BTK inhibitors (cardiovascular issues, coagulation function abnormalities, active infections, etc.); 2. Presence of other uncontrolled malignant tumors; 3. Severe heart failure (NYHA class 3-4); 4. Use of other anti-tumor treatments not included in this study protocol; 5. Patients known to be HIV antibody positive; 6. Pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression-free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival;Best objective response rate;Complete remission rate ;Adverse event; | — |
Countries
China
Contacts
Public ContactLi Zengjun
Affiliated Cancer Hospital of Shandong First Medical University
Outcome results
None listed