Patients undergoing laparoscopic hysterectomy
Conditions
Interventions
Tegileridine postoperative analgesia group (Group E):Tegileridine was used for postoperative intravenous controlled analgesia
Sufentanil postoperative analgesia group (Group S):Sufentanil was used for postoperative intravenous controlled analgesia
Sponsors
Chengdu Second People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Female, aged 18-65 years; 2. Body mass index (BMI) 18.0-30.0 kg/m^2; 3.ASA grade ?-?; 4. Patients undergoing elective laparoscopic hysterectomy and requiring postoperative patient-controlled intravenous analgesia; 5. Understand the purpose and procedures of the trial, voluntarily participate in the trial, and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Use opioid drugs or tramadol for more than 7 days before the operation; 2. Chronic pain, constipation, other intestinal dysfunction before surgery or after radiotherapy and chemotherapy; 3. Those who are allergic to opioid drugs or anesthetic and analgesic drugs specified in the protocol; 4.1 History of drug and alcohol abuse within the year; 5. Liver dysfunction; 6. Severe respiratory depression, such as oxygen saturation below 90%; 7. Known or suspected gastrointestinal obstruction, including paralytic ileus; 8. History of surgery involving the intestines, bladder or gastrointestinal tract; 9. The researchers believe that the subjects cannot tolerate it, cannot cooperate to complete the trial, or have other situations where they are not suitable to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time of first postoperative exhaust; | — |
Secondary
| Measure | Time frame |
|---|---|
| The time of regular meal;The time of tolerate solid food;The time of first defecation;Incidence of postoperative intestinal obstruction;Postoperative blood potassium level;Resting and exercise pain scores (NRS) at 0.5, 2, 6, 12, 24, 48 hours after surgery;Complications of analgesia ;Ramsay score;Postoperative analgesic drug consumption in12, 24, 36, 48 hours;Times of PCA;Times of remedial analgesia;RCSQ score on the day of surgery and the day after surgery;Postoperative recovery quality scores 24 hours, 48 hours, and one week after surgery (QOR-15); | — |
Countries
China
Contacts
Public ContactYu Huang
Chengdu Second People's Hospital
Outcome results
None listed