Overweight or obesity
Conditions
Interventions
Nutrition Intervention Group:Time-restricted eating (eating window limited to 8 hours)
free eating group:Dietary guidance and meal provision
Sponsors
The First Affiliated Hospital of USTC
Eligibility
Sex/Gender
All
Age
25 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Medical workers aged between 25 and 60 years old with a body mass index (BMI) between 24~45 kg/m²; 2. There has been shift work in the past three months. Shift work is defined as work arrangements outside normal working hours from 8:00~21:00 more than three times a month; 3. The daily eating window is more than 10 hours, and there is no fasting experience in the past 3 months; 4. Long-term resident of the local area, and no long-term plans to go out in the next six months, and absent from shift work for no other reason, that is, can continue the current shift work situation until the end of the entire intervention period; 5. Agree and be willing to strictly abide by the requirements of this intervention trial, including questionnaires, clinical examinations, and biological sample collection such as blood collection during the acceptance process, as well as wearing wearable devices.
Exclusion criteria
Exclusion criteria: 1. Suffering from clinically significant insomnia symptoms; 2) Have regular fasting habits (defined as fasting for 15 hours per day or complete 12 24-hour fasts within the past year), or have a daily eating window of 8 hours or less, and the possibility of acute allergic reactions to the interventions of this project; 3. Significant change in body weight in the past 3 months (>=3kg); 4. Currently suffering from acute or unstable chronic diseases, such as diabetes mellitus with unstable blood sugar control, severe cardiovascular disease, kidney disease, heart disease, liver disease, lung disease or neurological disease, etc., as well as gastrointestinal abnormalities, eating disorders, history of gastrointestinal surgery, cancer, infectious diseases or mental health diseases, etc., or using drugs that may affect blood sugar levels, weight or compliance, or being diagnosed with coagulation dysfunction, severe anemia; 5. Use of weight loss drugs, special drugs (such as glucocorticoid drugs, etc.) or other drugs that may affect the study weight and obesity-related biological indicators in the past 3 months; 6. Long-term alcoholism, or excessive alcohol intake (men drink more than 25 grams of alcohol per day, women drink more than 15 grams); 7. Women who are pregnant or lactating, or currently participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| weight;BMI;Visceral fat area; | — |
Secondary
| Measure | Time frame |
|---|---|
| Waist circumference;Hip circumference;body composition;Blood glucose;Blood lipids;Metagenomics;Blood ketone levels;Sleep indicators;Metabolomics;Composite Phase Deviations;Inflammation and oxidative stress;6-sulfamethoxy melatonin;Abdominal MRI;Immunomics; | — |
Countries
China
Contacts
Public ContactShuang, Rong
The First Affiliated Hospital of USTC
Outcome results
None listed