ICU patients with non-mechanical ventilation
Conditions
Interventions
Butorphanol tartrate group:None
Hydromorphone group:None
Sponsors
The People's Hospital of Baiyun District Guangzhou
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years; 2.Non-mechanically ventilated patients (including those who have been weaned from mechanical ventilation) with an expected ICU stay of >72 hours; 3.Patients with moderate to severe pain (NRS = 4 or BPS = 5, CPOT = 3) treated with hydromorphone or buprenorphine tartrate for analgesia, aiming to achieve comfort and safety, and to facilitate the implementation of life support measures; 4.Obtain the informed consent of patients or family members.
Exclusion criteria
Exclusion criteria: 1.Pregnant or breastfeeding; 2.Confirmed acute severe intracranial or spinal neurological diseases caused by vascular, infectious, intracranial expansion, or injury; 3.Presence of non-compensated acute circulatory failure (severe hypotension with MAP<55 mmHg despite adequate fluid resuscitation and vasopressor therapy); 4.Severe bradycardia (heart rate <55 beats per minute) or suffering from second- or third-degree atrioventricular block (except for those with a pacemaker installed); 5.Inability to obtain pain scores or any condition that may severely interfere with the collection of study data; 6.A history of long-term use of opioids or opioid addiction; 7.A known history of allergy to any of the study drugs; 8.Suffering from severe or acute asthma, or accompanied by severe carbon dioxide retention, head injury, or intracranial damage leading to respiratory depression; 9.Intestinal obstruction in the danger period (patients with existing or progressive risk of gastrointestinal obstruction, especially those with paralytic ileus); 10.Having participated in this study before or concurrently participating in any other interventional study (any study that assigns patients to different treatment groups).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal flora structure and diversity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fecal Calprotectin;Serum IL-6/IL-10; | — |
Countries
China
Contacts
Public ContactWang Shengnan
The People 's Hospital of Baiyun District Guangzhou; Southern Medical University Southern Hospital
Outcome results
None listed