Skull base diseases
Conditions
Interventions
Absorbable polymer tissue sealant membrane group:None
Control group:None
Sponsors
Huashan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: The absorbable polymer tissue sealing film group was selected as the standard 1. Age greater than or equal to 18 years old and less than 85 years old; 2. Cerebrospinal fluid leakage and low flow during nasal endoscopic surgery due to skull base disease, Kelly grade 1-2; 3. Signed informed consent form. 4. Patients who have actually used absorbable polymer tissue sealing membrane therapy according to the investigator's routine treatment practice decision. Control group selection criteria 1. Age greater than or equal to 18 years old and less than 85 years old; 2. Cerebrospinal fluid leakage and low flow during nasal endoscopic surgery due to skull base disease, Kelly grade 1-2; 3. Signed the informed consent form for the collection and preservation of biological and information resources in Huashan Hospital Affiliated to Fudan University; 4. Patients who have actually used artificial meningeal or autologous fat or fascial tamponade therapy according to the investigator's decision of routine treatment practice. 5. Patients who have been followed up for long-term postoperative review and follow-up at Huashan Hospital Affiliated to Fudan University and have generated the disease course and related follow-up information required for the study.
Exclusion criteria
Exclusion criteria: Exclusion criteria for absorbable polymer tissue sealing membrane group 1. Cerebrospinal fluid leakage and high flow after nasal endoscopic surgery Kelly >=3 grade; 2. History of recurrent sinusitis, otitis media, and migraine; 3. Have a history of falling to skull base fracture or open head injury in the past six months, or have undergone external ventricular drainage or craniotomy in the past six months; 4. Study participants with hydrocephalus at the time of inclusion; 5. Those with severe infection, anemia (Hb=3 grade; 2. History of recurrent sinusitis, otitis media, and migraine; 3. Have a history of falling to skull base fracture or open head injury in the past six months, or have undergone external ventricular drainage or craniotomy in the past six months; 4. Study participants with hydrocephalus at the time of inclusion; 5. Those with severe infection, anemia (Hb<60g/L), hypoproteinemia (Alb<30g/L); 6. Study participants with impaired coagulation due to drugs or other reasons; 7. Those with malignant tumors and cachexia; 8. Patients with autoimmune diseases or those who use immunosuppressants; 9. Pregnant or lactating women; 10. The investigator thinks it is inappropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative CSF leakage; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative intracranial infection;Postoperative intracranial pneumatosis;Postoperative sinusitis; | — |
Countries
China
Contacts
Public ContactYongfei Wang
Huashan Hospital Affiliated to Fudan University
Outcome results
None listed