Diabetes mellitus complicated with hyperuricemia
Conditions
Interventions
observation group:Empagliflozin and Metformin
control group:Metformin
Sponsors
The First Affiliated Hospital of Guilin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 18 to 70 years old (inclusive), gender unrestricted; 2. Confirmed with type 2 diabetes according to the "Chinese Guidelines for the Prevention and Treatment of Diabetes Mellitus (2024 Edition)", with glycated hemoglobin levels between 6% and 9%; 3. Meeting the diagnostic criteria for hyperuricemia as per the "2023 Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia-related Diseases in China", without painful attacks, and with uric acid levels between 420 and 480 µmol/L; 4. Able to understand the content and methods of this study.
Exclusion criteria
Exclusion criteria: 1. People who are allergic to canagliflozin, metformin hydrochloride or any of the excipients. 2. Contraindicated groups: Severe renal failure (eGFR < 45 mL/min/1.73m^2)acute conditions that may affect renal function, such as dehydration, severe infection, shock diseases that can cause tissue hypoxia (especially acute diseases or deterioration of chronic diseases), such as decompensated heart failure, respiratory failure, recent myocardial infarction and shock severe infection and trauma, major surgery, clinical hypotension and hypoxia, etc.pre-diabetic coma liver failure, acute alcohol poisoning, alcoholism uncorrected vitamin B12 and folic acid deficiency; 3. Pregnant women, lactating women and women of childbearing age who are unwilling to take reliable contraceptive measures. 4. Type 1 diabetes. 5. People who have experienced diabetic ketoacidosis, lactic acidosis or hyperosmolar non-ketotic coma within the last 6 months and required hospitalization. 6. Severe hypoglycemic events of unknown cause that required assistance from others to recover have occurred within the past 6 months; or frequent hypoglycemia: such as two or more hypoglycemic events (blood glucose < 3.9 mmol/L) within one month before screening. 7. Those with a history of recurrent urinary tract infections and/or genital infections; 8. Acute gouty arthritis attack period; 9. Those with critical conditions that make it difficult to make an accurate assessment of the efficacy and safety of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HbA1c;Uric acid; | — |
Countries
China
Contacts
Public ContactHuang Lili
The First Affiliated Hospital of Guilin Medical University
Outcome results
None listed