Acute Respiratory Distress Syndrome
Conditions
Interventions
Case series:no
Sponsors
Hengshui People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–85 years; 2. Meets the 2023 global definition of ARDS; 3. Intubated and deeply sedated on invasive mechanical ventilation; 4. Expected ICU stay >= 7 days; 5. Internal jugular or subclavian central venous catheter in place for treatment; 6. Voluntary participation with signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Body mass index (BMI) > 35 kg/m²; 2. Severe hemodynamic instability (e.g., mean arterial pressure 0.5 µg/kg/min); 3. Currently on extracorporeal membrane oxygenation (ECMO); 4. Contraindications to electrical impedance tomography (EIT): pacemaker implantation, thoracic deformity, unstable spinal injury, or open chest wound; 5. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| V/Q mismatch percent; | — |
Secondary
| Measure | Time frame |
|---|---|
| sRAGE;Ang-2;SP-D;IL-6;TNF-a;tidal volume;respiratory;minute ventilation;PEEP;FiO2;driving pressure;plateau pressure;length of stay;ventilator-free days at day 28;ICU mortality (rate); | — |
Countries
China
Contacts
Public ContactSun Yue
Hengshui People's Hospital
Outcome results
None listed