Postoperative inflammatory response after esophagectomy
Conditions
Interventions
Low-dose dexamethasone(DXM) group:Dexamethasone 5mg iv
High-dose dexamethasone(DXM) group:Dexamethasone 15mg iv
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. ASA I-III level; 3. Scheduled for thoracoscopic esophagectomy (open chest or thoracoscopic/ artificial pneumothorax combined with laparoscopic or open abdominal surgery); 4. Sign informed consent.
Exclusion criteria
Exclusion criteria: 1.Glucocorticoids or immunosuppressants were used within 1 month before surgery; 2.Diabetes mellitus (HbA1c>=7.0%) or fasting blood glucose >=11.1mmol/L; 3.Active infection; 4.Hepatic and renal dysfunction (Child-Pugh B/C or eGFR<30).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Highest serum CRP (mg/L) within 3 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hyperglycemic events (blood glucose >10mmol/L) within 7 days after surgery;Opioid consumption over 72h after surgery;Length of postoperative hospital stay;QoR-15 score at 72 h after surgery;Postoperative Complications;CRP at 24, 48, and 72 h; | — |
Countries
China
Contacts
Public ContactPeng Ke
The First Affiliated Hospital of Soochow University
Outcome results
None listed