Parkinson's disease
Conditions
Interventions
Movement disorders:NA
Control group:NA
Sponsors
The First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients who were initially diagnosed and had not yet received PD treatment, with a Mini Mental State Examination (MMSE) score > 26, excluding those with concurrent dementia. The diagnosis was based on the 2015 MDS diagnostic criteria. 2.Age >= 18 years, right-handed (to minimize interference from differences in hand function). Experimental group: Patients clinically diagnosed with movement disorders (such as Parkinson's disease, essential tremor, etc.). Control group: Healthy volunteers matched for age and gender, with no history of neurological diseases or writing disorders. 3.Functional requirements: Possess basic writing ability (able to independently complete drawing of straight lines, Chinese characters, and graphics); corrected vision >= 0.6, with no severe hand joint damage or pain that affects writing. 4.Voluntarily sign the informed consent form (for patients with cognitive impairment, the consent form must be signed by a legal guardian).
Exclusion criteria
Exclusion criteria: 1.Confounding diseases that may interfere: Presence of other neurological diseases (such as stroke, amyotrophic lateral sclerosis); Severe psychiatric disorders (such as schizophrenia, severe depression) or cognitive impairment (MMSE score = 20); Family history of neurodegenerative diseases, or systemic diseases such as diabetes and other cardiovascular and cerebrovascular diseases. 2.Medication/Treatment Interference: Undergone hand surgery or botulinum toxin injection treatment in the recent period (within 3 months); Taking medications that may affect motor function (such as antipsychotics, sedatives). 3.Functional Limitations: Inability to cooperate in completing standardized writing tasks (e.g., severe tremors rendering handwriting unrecognizable); Compatibility issues with data collection devices (e.g., left-handed individuals unable to use a right-handed writing tablet).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The levels of candidate recombination-related proteins: IL-1ß, IL-6, TNF-a, and a-syn molecules ; | — |
Countries
China
Contacts
Public ContactMingshu Mo
The First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed