Colorectal cancer
Conditions
Interventions
Control group:Oral placebo 2 weeks before surgery
Intervention group:Oral administration of agmatine 2 weeks before surgery
Sponsors
Tianjin Union Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-75 years old, gender is not limited; 2. The patient was diagnosed with CRC through preoperative pathology and was assessed to have anxiety, but was able to undergo surgical resection; 3. According to the modified Response Evaluation Criteria in Solid Tumors (mRECIST), there must be at least one target lesion that can be evaluated; 4. Karnofsky Performance Status (KPS) score >= 60; 5. Expected survival duration >= 12 weeks; 6. Prior to enrollment or during the study period, the subject has not received systemic treatments such as chemotherapy, immunotherapy, or targeted therapy; 7. The patient and their family are willing to cooperate with follow-up visits.
Exclusion criteria
Exclusion criteria: 1. Age under 18 years old or over 75 years old; 2. Pregnant and lactating women; 3. Merge severe cardiovascular system complications, cerebrovascular system complications, active hepatitis, and severe liver and kidney dysfunction; 4. Expected survival time<12 weeks; 5. Refuse to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response Rate of Anxiety Symptoms;Cancer Pain Response Rate;Progression-Free Survival,PFS;Overall Survival, OS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Edmonton Symptom Assessment System;Functional Assessment of Cancer Therapy - Colorectal; | — |
Countries
China
Contacts
Public ContactZhang Chunze/Zhang Qinghuai
Tianjin Union Medical Center
Outcome results
None listed