Consciousness Impairment
Conditions
Interventions
control group:Conventional rehabilitation treatment and drug-induced awakening treatment (including amantadine, zolpidem, angong Niuhuang Pills, etc.).
light group:The light therapy group received light therapy on the basis of conventional rehabilitation.
:810nm0.9W/cm243.2J/cm2. :40Hz,50%,1200(20). :20,1/,10. :40Hz50%1200s810nmW=0.9 W/cm2×,. :((DLPF
TI group:The TI treatment group received TI treatment on the basis of routine rehabilitation.
Scheme: Low intensity stimulation 4mA, twice a day for 2 hours (9:00-11:00 am, 15:00-17:00 PM), continuous
light+TI group:The light + TI treatment group received light and TI combined treatment on the basis of conventional rehabilitation treatment.
The specific protocol was the same as above, and the inte
Sponsors
Ankang Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Consciousness impairment caused by various reasons such as traumatic brain injury, cerebral hemorrhage, cerebral infarction, and hypoxic-ischemic encephalopathy, with a coma lasting more than 14 days, and the degree of consciousness impairment is assessed as minimally conscious state; 2. Age between 18 and 65 years; 3. Stable vital signs and no severe complications; 4. Family informed and consented.
Exclusion criteria
Exclusion criteria: 1. Patients with intracranial metallic implants or cardiac pacemakers, or those contraindicated for MRI examinations; 2. Individuals with organic brain disorders, prior traumatic brain injuries, or surgical histories; 3. Participants with documented mental health conditions, neurological disorders, or substance abuse that may compromise study efficacy assessment as determined by investigators; 4. Pregnant or breastfeeding women; 5. Patients experiencing uncontrollable frequent seizures following trauma; 6. Those with contraindications to transcranial magnetic stimulation (TMS) or transcranial near-infrared light therapy (NIR); 7. Patients who have received phototherapy or other physical interventions (e.g., transcranial magnetic stimulation, transcranial electrical stimulation, etc.) within the past 30 days; 8. Inability to provide informed consent; 9. Other circumstances deemed unsuitable for study intervention by investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coma Recovery Scale-Revised(CRS-R);Full Outline of UnResponsiveness(FOUR); | — |
Secondary
| Measure | Time frame |
|---|---|
| electroencephalogram (EEG);evoked potential; multimoding MRI;PET-CT; | — |
Countries
China
Contacts
Public ContactDongbo Li
Ankang Central Hospital
Outcome results
None listed