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Effect of low-dose esketamine on perioperative analgesia and postpartum depression in patients with cesarean section

Effect of low-dose esketamine on perioperative analgesia and postpartum depression in patients with cesarean section

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500109502
Enrollment
Unknown
Registered
2025-09-19
Start date
2025-09-20
Completion date
Unknown
Last updated
2025-09-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cesarean section patient

Interventions

Ketamine group:After the delivery of the fetus, in the esketamine group: intravenous injection of esketamine 0.5mg/kg
Control group:After the delivery of the fetus, the control group: injected with an equal volume of saline

Sponsors

Second People's Hospital of Hefe
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1. The parturient is voluntary and signs the informed consent form; 2.ASA Grade I -II; 3. Perform elective cesarean section; 4.20 years old 80×10^9/L, no obvious abnormality in coagulation function, or PT prolonged < 3 seconds, APTT prolonged < 10 seconds;

Exclusion criteria

Exclusion criteria: 1. Psychiatric and neurological drugs were used before the operation; 2. Those with severe or unstable internal diseases such as heart, liver, kidney, endocrine, and blood disorders; 3. Unable to independently understand and complete the content of the scale; 4. Those with severe depressive symptoms who are diagnosed by a psychiatrist as requiring immediate antidepressant treatment;

Design outcomes

Primary

MeasureTime frame
The EPDS score was performed on the 3rd and 6th week after delivery;

Countries

China

Contacts

Public ContactWang Zicheng

Second People's Hospital of Hefei

527640484@qq.com+86 551 6296 5371

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026