Chronic postsurgical pain
Conditions
Interventions
A group:Traditional Patient-Controlled Intravenous Analgesia (PCIA)
B group:Non-chloramine ketamine cocktail therapy (peripheral blockade anti-inflammatory)
C group:Cocktail therapy with esketamine (peripheral blockade, anti-inflammatory, central blockade)
Sponsors
Jiangdu People's Hospital affiliated to Yangzhou University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 50-75 years, ASAI.-III. class; 2. Preoperative Numeric Score (NRS) for Resting Pain (NRS) <=3 points; 3. No history of esketamine allergy, psychiatric illness, joint infection or severe liver and kidney insufficiency.
Exclusion criteria
Exclusion criteria: 1. Coagulation dysfunction and anatomical abnormalities of the peripheral nerve of the prosthesis (such as MRI showing that the distance between the nerve and the prosthesis is <5mm); 2. History of long-term use of opioids or anti-epileptic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of CPSP; | — |
Secondary
| Measure | Time frame |
|---|---|
| The difference in activity pain NRS between groups at 48 hours post-surgery;Total opioid consumption; | — |
Countries
China
Contacts
Public ContactMeiyu Liu
Jiangdu People's Hospital affiliated to Yangzhou University
Outcome results
None listed