Post-stroke aphasia
Conditions
Interventions
Stroke aphasia group:None
Healthy Control Group:none
Stroke non-aphasia group:None
Sponsors
Wuxi Mental Health Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Non-aphasic stroke patients: (1) Subacute stroke patients aged 40-80 years (with an illness duration of less than 3 months); (2) First occurrence of stroke confirmed by magnetic resonance imaging (MRI) or computed tomography (CT) and limited to unilateral lesions on the left side; (3) Right-handed, native Chinese speaker, with no professional vocal or instrumental training experience; (4) At least received elementary education, with normal visual and auditory perception. 2. Aphasic stroke patients: (1) Aged 40-80; (2) Diagnosed by a neurologist with a first stroke, and having unilateral lesions on the left side, with an illness duration of more than 1 month; (3) Assessed by Western aphasia test as a patient with non-fluent aphasia; (4) Right-handed, native Chinese speaker, with normal language function before the onset, and no professional vocal or instrumental training; (5) Boston Diagnostic Aphasia Examination (BDAE) levels I-III; (6) Education level above elementary school, with basic normal vision and hearing.
Exclusion criteria
Exclusion criteria: 1. Non-aphasic patients with stroke: (1) Comorbid visual or auditory impairments affect language assessment and subjects; (2) Contraindications for transcranial magnetic stimulation (TMS) technology and MRI (such as skull defects, skin injuries at the stimulation site, intracranial implants, pacemakers, or implanted drug pumps); (3) Severe cognitive dysfunction, subjects unable to cooperate with assessment and treatment; (4) Subjects with other neurological disorders (such as Parkinson's disease, Alzheimer's disease, or Huntington's disease). 2. Aphasia patients with stroke: (1) History of drug or alcohol abuse, history of seizures, or history of neuropsychiatric disorders; (2) Contraindications involving TMS and fMRI (for example, skull defects or skin injuries at the stimulation site, intracranial implants, cardiac pacemakers, and implanted drug pumps); (3) History of neurosurgical treatment; (4) Severe cognitive impairment, unable to cooperate with assessment and treatment; (5) Other neurological disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Granger causality effective connection value (GC); | — |
Secondary
| Measure | Time frame |
|---|---|
| WesternAphasia Battery, WAB; | — |
Countries
China
Contacts
Public ContactDongdong Jiang
Wuxi Mental Health Center
Outcome results
None listed