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The molecular mechanism of pelvic organ prolapse (POP) caused by ferroptosis of sacral ligament tissue induced by PTGS2

The molecular mechanism of pelvic organ prolapse (POP) caused by ferroptosis of sacral ligament tissue induced by PTGS2

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500109456
Enrollment
Unknown
Registered
2025-09-18
Start date
2025-01-30
Completion date
Unknown
Last updated
2025-09-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pelvic Organ Prolapse,POP

Interventions

NO Pelvic Organ Prolapse Group:None

Sponsors

The First People's Hospital of Yunnan Province
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1.It meets the diagnostic criteria of POP, and is graded as ?, ?, ? and ? according to POP-Q; 2.In the past 3 months, he has not received Chinese and Western drugs related to this disease; 3.Patients participated in the study knowingly and voluntarily.

Exclusion criteria

Exclusion criteria: 1.Patients participated in the study knowingly and voluntarily; 2.Patients with malignant tumors; 3.Patients with severe pelvic infection or pelvic endometriosis that destroys the normal structure of the sacral ligament; 4.Patients with systemic diseases, such as diabetes, hormone therapy diseases (acute and chronic nephritis, etc.).

Design outcomes

Primary

MeasureTime frame
The amount of free iron;Expression of PTGS2 mRNA;Expression of PTGS2 protein;

Secondary

MeasureTime frame
Serum estradiol level;MDA content;

Countries

China

Contacts

Public ContactZhao Chongyi

The First People's Hospital of Yunnan Province

1114773544@qq.com+86 13888908204

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026