sleep disorders
Conditions
Interventions
Remimazolam group:Remimazolam induction and maintenance
Sponsors
The First Affiliated Hospital of the University of Science and Technology of China(Anhui Provincial Hospital)
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) patients undergoing elective total knee arthroplasty; (2) age >=65 years old; (3) ASA physical status I~III; (4) BMI=30 kg/m2 or waist-to-hip ratio (WHR) > 0.9 in men or > 0.85 in women.
Exclusion criteria
Exclusion criteria: (1) Severe cardiac arrhythmias, including sick sinus syndrome, symptomatic bradycardia (heart rate below 50 beats per minute), or second- or third-degree atrioventricular block without pacemaker implantation; (2) Severe renal insufficiency (requiring renal replacement therapy); (3) Child-Pugh C grade; (4) ASA physical status >= IV grade; (5) Allergy to the study drug; (6) Patients with known chronic sleep disorders and those who are on long-term benzodiazepine therapy; (7) Patients with preoperative psychiatric disorders or cognitive dysfunction and who are unable to cooperate with the scoring; (8)Other circumstances deemed ineligible for study participation by investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of sleep; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety score;The incidence of postoperative delirium;Postoperative recovery quality score;Pain score;Plasma concentrations of inflammatory cytokines/factors; | — |
Countries
China
Contacts
Public ContactWang Sheng
The First Affiliated Hospital of the University of Science and Technology of China(Anhui Provincial Hospital)
Outcome results
None listed