Chronic Obstructive Pulmonary Disease
Conditions
Interventions
Experimental group:General anesthesia with Remimazolam Besylate
Sponsors
Shanghai First People's Hospital Jiuquan Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-75 years old; 2. Consistent with COPD diagnosis; 3. Laparoscopic surgery under general anesthesia at an elective stage; 4. American Society of Anesthesiologists (ASA) grade I.-III; 5. Agree to participate in this trial and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Body mass index (BMI) >=30 kg/m²; 2. History of brain or thoracic/abdominal aortic aneurysm; 3. Allergy to any drug used in this study; 4. History of severe hepatic impairment, i.e., Child-Pugh grade C; 5. Currently receiving maintenance dialysis treatment; 6. Congestive heart failure, NYHA cardiac function class III or IV. 7. Untreated or unstable ischemic heart disease; 8. History of severe aortic or mitral valve disease; 9. History of frequent premature ventricular contractions, frequent atrial premature contractions or atrial fibrillation; 10. Current use of antidepressants or antipsychotics; 11. Mean arterial pressure (MAP) < 70 mmHg before anesthesia induction; 12. Presence or anticipation of airway management difficulties; 13. Failure of first intubation; 14. Judged by the investigator to be ineligible for inclusion; 15. Absolute contraindications to TEE (history of esophageal stricture, variceal bleeding, etc.); 16. Pregnant or lactating women; 17. Refusal to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac Output (CO);Right ventricular area change fraction(RV-FAC);Tricuspid Annular Plane Systolic Excursion (TAPSE);Right Ventricular Diastolic Function (E/e'); | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean Arterial Pressure (MAP);Heart Rate (HR);Pulse oxygen saturation(SpO?);Research on total drug dosage;Total dosage of Vasoactive Drugs;Anesthesia recovery time;Incidence of adverse events; | — |
Countries
China
Contacts
Public ContactChen Fu
Shanghai First People's Hospital Jiuquan Hospital (Jiuquan People's Hospital)
Outcome results
None listed