carotid artery stenosis
Conditions
Interventions
Propofol group (control group):Anesthesia was induced by intravenous injection of propofol 1.5 mg/kg, sufentanil 0.3 µg/kg and rocuronium 0.6 mg/kg. Anesthesia was maintained by continuous infusion of
ciprofol group (Research Group):Anesthesia was induced with intravenous ciprofol 0.3 mg/kg, sufentanil 0.3 µg/kg and rocuronium 0.6 mg/kg. Anesthesia was maintained by continuous infusion of ciprofol
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age 65-85 years old; 2. 18 kg/m^2 < BMI < 28 kg/m^2; 3. American Society of Anesthesiologists (ASA) grade I-III; 4. Patients scheduled for carotid endarterectomy; 5. Informed consent was obtained from patients and their families;
Exclusion criteria
Exclusion criteria: 1. History of cardiovascular diseases such as severe hypertension (systolic blood pressure >=180 mmHg), unstable angina pectoris, severe arrhythmia, and cardiac insufficiency; 2. Severe liver and kidney dysfunction; 3. Respiratory failure (PaO2<60mmHg); 4. History of stroke less than 3 months; 5. Carotid artery occlusion; 6. Allergic to drugs such as ciprofol and propofol and their components; 7. Patients with a history of mental illness or dementia who were unable to cooperate with the study; 8. Patients with unclear temporal window ultrasound exposure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rSO2 on the surgical side; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean velocity of bilateral middle cerebral artery;Bilateral rSO2;Prtial pressure of end tidal carbon dioxide;Biphasic index ;Mean Arterial Pressure;Heart rate;Arterial blood gas analysis;Consumption of propofol;Consumption of ciprofol;Consumption of sufentanil;Consumption of remifentanil;Use of vasoactive agents;Consumption of norepinephrine;Occurrence of adverse cardiovascular events;Awakening time;Extubation time;Recovery time of orientation;Occurrence of intraoperative awareness;Occurrence of agitation during the recovery period;Length of stay in PACU;RASS score;Occurrence of postoperative complications; | — |
Countries
China
Contacts
Public ContactMa Yanhui
Xuanwu Hospital, Capital Medical University
Outcome results
None listed