Healthy females or males aged between 18 and 60 years old, those who are positive in the lactic acid stinging test, with sensitive, reddish and dry facial skin, and the ITA° value of the normal facial skin being between 28° and 41°. The tested area has been diagnosed by a clinical doctor as melasma or seborrheic keratosis, and there is at least one part where the difference in ITA° value from the
Conditions
Interventions
Test group:Provide the test sample (Arbutin Shining White Light-transmitting Micro Essence Cream) to the subjects in this group and instruct them to use the samp
Sponsors
Dematology Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Healthy females or males aged between 18 and 60 years old. 2. Those who are positive for the lactic acid sting test. 3. Those with sensitive and reddish facial skin, and dry skin on the face. 4. Those whose ITA° value of the normal facial skin is between 28° and 41°. 5. Those without a history of allergic diseases and without a history of allergy to cosmetics or other topical preparations. 6. Those without a past history of photosensitive diseases and who have not used drugs affecting photosensitivity recently. 7. The tested area has been diagnosed as melasma or seborrheic keratosis by a clinical doctor, and there is at least one area where the ITA° difference from the adjacent surrounding skin is greater than 10°, and the diameter is not less than 3mm. 8. Those with good compliance with this project and good communication skills. 9. Those who are willing to participate in follow-up and undergo relevant non-invasive tests. 10. Those who can understand the test process, voluntarily participate in the test and sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those with a history of skin diseases such as psoriasis, eczema, atopic dermatitis, severe acne, etc. 2. Those who have taken oral or topical anti-inflammatory drugs such as corticosteroids in the past 1 month. 3. Those who have used any products or drugs that affect skin color such as alpha-hydroxy acids, salicylic acid (e.g., hydroquinone preparations) in the past 2 months. 4. Those who have used retinoid preparations on the test site or received cosmetic medical treatments such as chemical peeling, laser therapy, and pulsed light therapy in the past 3 months; 5. Those who are unavoidably exposed to sunlight for a long time. 6. Those who have participated in other clinical trials in the past 2 months. 7. Women who are planning to become pregnant, pregnant, or lactating. 8. Those with obvious scars, pigmentation, atrophy, port-wine stains, sunburns, wounds, excessive hair, abrasions, tattoos, or other blemishes on or near the skin test site that may affect the judgment of test results. 9. Those with highly sensitive constitutions, or known to be allergic to ingredients in cosmetics or daily chemical products, alcohol, rubber, drugs, etc. 10. Those with other iatrogenic issues that may affect the test results (such as having a history of coagulation disorders, severe hyperglycemia, hypertension, hyperlipidemia, mental illness, or other major diseases). 11. Those who are deemed unsuitable for participating in the trial by other clinical evaluations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The content of melanin in the skin; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical assessment questionnaire;VISIA CR spot analysis;Skin colorimetric ITA° value;Research participant self - assessment questionnaire;Lactic acid stinging test;The water content of the stratum corneum of the skin;Transepidermal water loss; | — |
Countries
China
Contacts
Public ContactYe Li
Dematology Hospital of Southern Medical University
Outcome results
None listed