Pancreatic space-occupying lesions
Conditions
Interventions
Index test:The diagnostic model for four-category classification (PDAC, PNET, PCN, inflammatory lesions) of pancreatic space-occupying lesions based on the integration of multi-parameter MRI and clini
Sponsors
The First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age between 18-75 years, without gender restriction; 2.Highly suspected pancreatic space-occupying lesions based on clinical assessment, ultrasonography and/or CT preliminary examination; 3.Planning to undergo surgical resection or endoscopic ultrasound-guided fine-needle aspiration biopsy at Southwest Hospital for definitive pathological diagnosis; 4.Able to complete the full MRI scanning sequences required by the study before surgery or biopsy; 5.No contraindications to MRI examination (such as implanted cardiac pacemakers, intracranial metallic foreign bodies, etc.); 6.Having complete clinical data, including basic patient information and laboratory test results (blood amylase, lipase, blood glucose, CA19-9, CEA, etc.); 7.No previous pancreatic-related treatments (surgery, radiotherapy, chemotherapy, interventional therapy, etc.); 8.Patient has normal cognitive function, able to understand and voluntarily sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1.Patients with severe cardiac and pulmonary dysfunction (American College of Cardiology heart function classification grade III or above or NYHA class III or above); 2.Severe liver and kidney dysfunction (Child-Pugh Class C liver dysfunction or eGFR<30ml/min/1.73m^2); 3.Pregnant or lactating women; 4.Patients with severe systemic infection or acute exacerbation of systemic diseases; 5.Patients unable to tolerate 45-minute MRI examination (such as severe claustrophobia); 6.Pancreatic lesions with diameter <1.0cm, difficult for accurate quantitative analysis; 7.Patients with previous pancreatic surgery, pancreatic trauma history, or who have received pancreatic radiotherapy, chemotherapy, or interventional treatment; 8.Patients with active malignant tumors in other systems; 9.Patients who cannot obtain definitive pathological diagnosis for any reason; 10.Patients participating in other clinical studies that may affect the evaluation of this study; 11.Other circumstances deemed unsuitable for participation in this study by the investigator;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AUC of the four-classification diagnostic model for pancreatic lesions integrating multi-parameter MRI with clinical indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| The ability to differentiate between malignant and benign lesions;Sensitivity, specificity and accuracy of the model; | — |
Countries
China
Contacts
Public Contactwei Chen
The First Affiliated Hospital of Army Medical University
Outcome results
None listed