Complex congenital heart disease
Conditions
Interventions
Normal oxygen perfusion group:Maintain the partial pressure of oxygen within the range of 60-120 mmHg during extracorporeal circulation.
High oxygen perfusion group:Maintaining the oxygen partial pressure within the range of PaO2: 200 - 300 mmHg during extracorporeal circulation.
Sponsors
Beijing Anzhen Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: 1) Infants within one year of age, including full-term neonates and infants; 2) Diagnosed with cyanotic congenital heart disease (CCHD), including conditions such as tetralogy of Fallot, transposition of the great arteries, pulmonary stenosis, single ventricle, coarctation of the aorta, etc.; 3) Weighing more than 2500 grams; 4) Undergoing elective or limited cardiac surgery; 5) First surgical procedure; 6) Informed consent signed by family members.
Exclusion criteria
Exclusion criteria: 1) Gestational age at birth is less than 33 weeks; 2) Undergone emergency surgery; 3) Participated in other clinical trials; 4) Accompanied by severe complications; 5) Presence of evident systemic infection or inflammation prior to surgery; 6) Patients or their legal guardians are unable to participate in follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perioperative incidence of major adverse events;Incidence of cardiac insufficiency; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of delayed chest closure;Leakage syndrome incidence;Incidence of acute lung injury;Incidence of acute liver injury;Incidence of acute kidney injury;Cardiac arrest;Mechanical Circulation Support (ECMO);Postoperative hospital stay;In-hospital mortality;Total postoperative fluid intake and outflow;ICU ventilator tube time;ICU retention time;Six-month readmission rate;1-year mortality; | — |
Countries
China
Contacts
Public ContactZhao Ju
Beijing Anzhen Hospital, Capital Medical University
Outcome results
None listed