Central pruritus caused by intrathecal morphine administration.
Conditions
Interventions
Ltchy Group:None.
Non-itchy group:None
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
Female
Age
25 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Cesarean section mothers under intraspinal anesthesia; 2. Morphine should be administered intraspinal. 3.ASA classification grades I - III; 4. Natural conception, single pregnancy; 5. Gestational age: 37 to 42 weeks; 6. Be between 25 and 40 years old; 7. Informed consent from the patient himself/herself or his/her legal representative; 8. Permanent residence in Anhui.
Exclusion criteria
Exclusion criteria: 1. Presence of contraindications to neuraxial anesthesia 2. Presence of contraindications to epidural use of morphine 3. Combined with diabetes mellitus (non-gestational diabetes), immune diseases, infectious diseases or digestive system diseases 4. Use of antibiotics or microbiotics (such as probiotics, prebiotics and synbiotics) within 3 months before birth 5. History of anxiety or depressive disorders 6. Refusal to Participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The differences in the microbiome and host transcriptome between pruritic and non-pruritic parturients.; | — |
Secondary
| Measure | Time frame |
|---|---|
| The differences of neurotransmitters in serum.;Postoperative Itching Score;Postoperative pain score;Whether urinary retention has occurred;Whether postoperative nausea .;Whether there is lower extremity motor block.;Whether respiratory depression occurs;Whether postoperative vomiting occur.; | — |
Countries
China
Contacts
Public ContactLiu Xuesheng;Liu Hu;Ye Lei
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed