Breast cancer
Conditions
Interventions
Dexmedetomidine nasal spray (Group D):At 30min before anesthesia induction, dexmedetomidine was sprayed into the nasal cavity, 1 spout was sprayed into each nostrils, and then 1 spout was sprayed into
Blank control group (Group C):Placebo saline was sprayed into the nasal cavity at 30min before induction of anesthesia, and 1 spout was sprayed into each nostril for 30s, then 1 spout was sprayed into
Sponsors
Department of Anesthesiology, The Central Hospital of Wuhan
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18~75 years old; 2. Female; 3. Breast cancer surgery, anesthesia time <=4 h; 4. American Society of Anesthesiologists (ASA) grade I.~III; 5. Body mass index (BMI) 18-30 kg/m²; 6. Able to voluntarily cooperate with this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women and women with a birth plan within 3 months; 2. Patients with severe cardiac, lung, liver, and kidney dysfunction; 3. Patients with severe neuropsychiatric disorders or cognitive dysfunction; 4. Sinus bradycardia ( 7 points.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PSQI score on the night after the surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| PSQI score on the 2nd and 3rd night after surgery;APAIS scores before and after medication administration;Time of extubation;Time to full consciousness;Duration of stay in the PACU;Usage of vasoactive drugs during anesthesia;Incidence of adverse events during anesthesia and recovery process;Patient and anesthesiologist satisfaction ratings;Postoperative VAS score on days 1-3;RASS scores before and after medication administration; | — |
Countries
China
Contacts
Public ContactYingge Liu
Department of Anesthesiology, The Central Hospital of Wuhan
Outcome results
None listed