Cerebral Venous Thrombosis
Conditions
Interventions
Steroid Add-on Therapy Group:Patients will receive steroid pulse therapy within 2 days after randomization (500 mg methylprednisolone per dose, once daily, intravenous drip for 3 days). For large veno
followed by 60 mg once daily, intravenous drip for 3 days
and then 40 mg once daily, intravenous drip for 3 days. If major gastrointestinal bleeding, spontaneous fracture, or recurrence of CVT occurs during steroid therapy, further administration of steroids
Standard Anticoagulation Group:No steroid will be used throughout the treatment course, and therapy will be administered in accordance with guidelines.
Based on the patient’s body weight, an appropria
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
14 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients with clinically and radiologically confirmed acute/subacute severe CVT. 1. The diagnosis of CVT must be established by an experienced neurologist based on the following criteria: Clinical presentation: Medical history, physical examination, and auxiliary examinations consistent with CVT diagnostic criteria. Radiological confirmation: Conventional magnetic resonance imaging (MRI) or magnetic resonance black-blood thrombus imaging (MRBTI) sequences. 2. Definition of acute/subacute: Time from onset to hospital admission <= 15 days or time from symptom exacerbation to hospital admission <= 15 days, with imaging showing thrombus characteristics consistent with acute/subacute signals (T1/T2-weighted sequences, contrast-enhanced MRI, or MRBTI). 3. Definition of severe (meeting any one of the following): Radiological evidence of venous cerebral infarction, cerebral hemorrhage, or subarachnoid hemorrhage. Clinical complications such as seizures or impaired consciousness. 4. Age between 14 and 80 years. 5. No restrictions on gender. 6. Agreement to participate in the study and provision of signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Age = 3; 8. Presence of brain herniation with refusal to undergo decompressive craniectomy, or lack of pupillary light reflex recovery after decompressive surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Rankin Scale Scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| National Institutes of Health Stroke Scale Scores; | — |
Countries
China
Contacts
Public ContactJiangang Duan
Xuanwu Hospital, Capital Medical University
Outcome results
None listed