Postoperative depression in patients after total laryngectomy
Conditions
Interventions
Ketamine Group:Administer 0.5 mg/kg of es ketamine within 30 minutes after anesthesia induction, and provide patient-controlled intravenous analgesia (PCIA) within 48 hours post-surgery. In the PCIA,
Control group:Infuse an equal amount of 0.9% saline within 30 minutes after anesthetic induction, PCIA for 48 hours post-operation, with sufentanil 2ug/kg and 0.25mg of palonosetron hydrochloride dilu
Sponsors
Shandong Second People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Ages 18-75; 2. American Society of Anesthesiologists (ASA) classification I-III; 3. Patients with laryngeal cancer or hypopharyngeal cancer who are scheduled for total laryngectomy; 4. Good consciousness and unobstructed communication; 5. Voluntarily participating in this study; 6. All signed informed consent forms, received education, and cooperated in data collection.
Exclusion criteria
Exclusion criteria: 1. Cognitive dysfunction; 2. Preoperative mental illness or use of antipsychotic medication; 3. Serious physical diseases such as heart, lung, or brain failure; 4. Drug intolerance; 5. Any other reasons that prevent cooperation with the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hospital Anxiety and Depression Scale,(HADS); | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-6?Kyn?Trp?BDNF;Brain Functional Magnetic Resonance Imaging; | — |
Countries
China
Contacts
Public ContactMing Hao
Shandong Second Provincial General Hospital
Outcome results
None listed