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A study on the therapeutic effect of probiotics on rheumatoid arthritis based on the gut-joint axis mechanism

A study on the therapeutic effect of probiotics on rheumatoid arthritis based on the gut-joint axis mechanism

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500109356
Enrollment
Unknown
Registered
2025-09-17
Start date
2025-03-01
Completion date
Unknown
Last updated
2025-09-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

RA(rheumatoid arthritis)

Interventions

treatment group:The treatment group was given probiotic treatment in addition to the basic treatment. The probiotics selected are complex lactic acid bacteria enteric-coated capsules. A course of trea
control group:The treatment was based on MTX (10 mg each time, orally, once a week).

Sponsors

Chun 'an County Hospital of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: (1) RA patients who meet the diagnostic criteria of Western medicine, aged 18 to 65 years old; (2) Joint function is at grade I to III; (3) No special treatment for rheumatoid arthritis has been received within the past month, and no antirheumatic drugs, glucocorticoids, Tripterygium wilfordii or biological agents have been used. (4) No non-steroidal anti-inflammatory drugs have been taken within the past week; (5) Be aware of the research risks and sign the informed consent form for clinical research.

Exclusion criteria

Exclusion criteria: (1) Those who do not meet the inclusion criteria; (2) Those who have concurrent other rheumatic diseases such as systemic lupus erythematosus, or suffer from special types of arthritis that affect joint function; (3) Patients with severe primary diseases of the cardiovascular, liver, kidney and hematopoietic systems, or those with mental disorders and tumors; (4) Those who have long relied on hormones and biological agents; (5) Pregnant women, lactating women, those with a history of alcohol allergy or a clear history of drug or food allergy; (6) The researchers, through assessment, found that those who were mistakenly included did not meet any of the inclusion requirements.

Design outcomes

Primary

MeasureTime frame
Laboratory-related indicators (serum ESR, RF, CRP levels);

Secondary

MeasureTime frame
Patient Visual Analogue Scale score;

Countries

China

Contacts

Public ContactXu Wei

Chun 'an County Hospital of Traditional Chinese Medicine

xuwei19870903@163.com+86 158 5811 7403

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026