Insomnia with anxiety and depression
Conditions
Interventions
Intervention group:Inhibitory transcranial ultrasound stimulation, 10 minutes/day, 7 days in total.
Control group:Transcranial ultrasound stimulation with intensity parameter of 0, 10 minutes/day, 7 days in total.
Sponsors
Xuanwu Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Right-handed patients aged between 18 and 65 years, regardless of gender; 2. Diagnosis of insomnia based on the diagnostic criteria for insomnia related to other psychiatric disorders in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV); 3. Meeting the DSM-IV structured clinical interview diagnostic criteria for generalized anxiety and depression; 4. Duration of insomnia >= 3 months; 5. PSQI score >= 7; 6. HAMA score >= 14; 7. HAMD-17 score >= 8; 8. If the patient is currently taking medication, they agree to maintain their current medication regimen throughout the entire trial; 9. Willingness to participate in the study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Have serious or unstable organic diseases, such as heart, liver, or kidney diseases; 2. Have a history of epilepsy, hydrocephalus, or other central nervous system diseases; 3. Suffer from mental disorders other than anxiety and mild to moderate depression (e.g., schizophrenia spectrum and other psychotic disorders, bipolar and related disorders, obsessive-compulsive and related disorders, etc.); 4. Insomnia caused by specific conditions such as anemia, hyperthyroidism, severe sleep apnea, restless legs syndrome, or shift work; 5. Pregnant or lactating women; 6. Presence of metal implants in the body, such as pacemakers, deep brain stimulation electrodes, cardiac stents, or other therapeutic devices; 7. Participated in any other clinical trial within one month prior to baseline.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of the severity of insomnia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical symptoms;Electrophysiology;Functional magnetic resonance imaging; | — |
Countries
China
Contacts
Public ContactLiu Chunyan
Xuanwu Hospital Capital Medical University
Outcome results
None listed