None
Conditions
Interventions
N0:0ug/kg neostigmine
N15:15ug/kg neostigmine
N30:30ug/kg neostigmine
N40:40ug/kg neostigmine
Sponsors
ZhuJiang Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18-65 years; no gender restriction (2) BMI 18-30 kg/m^2 (3) ASA physical status classification I-III (4) Patients scheduled to undergo non-cardiac surgery under general anesthesia with endotracheal intubation (5) Patients and their families are informed of the study details, voluntarily participate, and sign the informed consent form
Exclusion criteria
Exclusion criteria: (1) Allergy to any drug used in this study (2) Patients with neuromuscular disorders (3) Patients with severe hypertension or diseases of the heart, brain, liver, kidneys, lungs, endocrine system, etc. (4) Long-term use of psychotropic medications or presence of psychiatric disorders (5) Recent use of drugs affecting neuromuscular junction function (e.g., aminoglycoside antibiotics such as gentamicin, neomycin) (6) Conditions interfering with neuromuscular monitoring (e.g., deformity, trauma, hypoplasia, or surgical history) (7) Participation in other clinical trials within the past 30 days (8) Any other reason deemed by the investigator as grounds for exclusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuromuscular recovery time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to recovery of TOFr to 1.0;Probability of neuromuscular recovery;Hemodynamic fluctuations;Time in PACU;Quality of Recovery;Anesthesia satisfaction; | — |
Countries
China
Contacts
Public ContactShiyuan Xu
ZhuJiang Hospital of Southern Medical University
Outcome results
None listed