Intracranial atherosclerosis
Conditions
Interventions
Observation group:none
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 18-85 years; 2. Confirmed by MRA or CTA, carotid atherosclerotic stenosis of the Willis ring (less than 50%, greater than or equal to 50%, or occlusion); 3. mRS score <= 2 points; 4. No stroke or TIA, or more than 3 months since onset of stroke or TIA.
Exclusion criteria
Exclusion criteria: 1.Extracranial cervical artery stenosis > 50%; 2.Relative/absolute contraindications related to MRI safety (e.g., metallic implants, claustrophobia); 3.Clinically confirmed non-atherosclerotic causes of intracranial stenosis, such as dissection, vasculitis, moyamoya disease, embolism, or immune-mediated diseases; 4.Other confirmed etiological subtypes of stroke, including cerebral hemorrhage, subarachnoid hemorrhage, or cardioembolism; 5.Clinically diagnosed neurodegenerative disorders, such as Alzheimer’s disease, Lewy body dementia, frontotemporal lobar degeneration, or Parkinson’s disease; 6.Other comorbid medical histories that may interfere with endpoint event judgment and follow-up, including history of traumatic brain injury, multiple sclerosis, encephalitis, tumor, poisoning, syphilis, or severe cardiac, pulmonary, hepatic, renal, or endocrine diseases; 7.Refusal to sign informed consent; 8.Pregnant or lactating women will not be included in the PET/MRI substudy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| stroke event;cognitive status; | — |
Secondary
| Measure | Time frame |
|---|---|
| multimodel imaging index;Modified Rankin Scale (MRS) Score;Domain-specific Z-scores (Memory, Attention, Executive Function, Visuospatial, Language);blood biomarker;Comprehensive Z-scores of neuropsychological scales;Hamilton anxiety and depression scale; | — |
Countries
China
Contacts
Public ContactCaiyan Liu
Peking Union Medical College Hospital
Outcome results
None listed