Insomnia
Conditions
Interventions
Conventional treatment + anesthesia induction sleep balance group:On the basis of conventional treatment, dexmedetomidine combined with propofol was used to induce sleep balance
Conventional treatment group:Conventional treatment
Sponsors
The First People's Hospital of Zunyi
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age above 18 years, both males and females are eligible; 2.Meet the diagnostic criteria for insomnia disorder as defined by the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5); 3.Total score of the Pittsburgh Sleep Quality Index (PSQI) > 7; 4.Presence of anxiety or depressive symptoms, indicated by a Hamilton Anxiety Scale (HAMA) score >=14 and =7 and <=23, without meeting the full diagnostic criteria for an anxiety or depressive disorder; 5.Voluntarily participate in the treatment and have provided signed informed consent;
Exclusion criteria
Exclusion criteria: 1.Allergy to dexmedetomidine or propofol; 2.Presence of cardiac conduction block, severe ventricular dysfunction, severe hepatic or renal insufficiency, or other serious somatic diseases; 3.Abnormal blood pressure, bradycardia, or poorly controlled diabetes mellitus; 4.Detection of sleep apnea through polysomnography (PSG) conducted prior to treatment; 5.History of head trauma; 6.History of epilepsy, psychiatric disorders, or abnormal electroencephalogram (EEG) findings; 7.Known history of alcohol abuse or substance misuse; 8.Pregnancy, lactation, or planned pregnancy; 9.Educational level below elementary school or inability to comprehend the content of the rating scales used before and after treatment;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of sleep;Anxiety and depression score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Patients' experience scores regarding the induction process.;Multi-omics testing;Hyperarousal condition;Vital signs;Adverse reactions;Blood biomarkers;Quality of sleep;Clinical efficacy;Structure of sleep; | — |
Countries
China
Contacts
Public ContactXiong Liulin
The First People's Hospital of Zunyi
Outcome results
None listed