MSA,Multiple system atrophy
Conditions
Interventions
Intervention group:(1) Patients should receive comprehensive health education before surgery.(2) The implantation of plate electrodes under general anesthesia requires a surgical incision method, invo
Sponsors
Department of Neurology, Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Meets the diagnostic criteria for possible or probable multiple system atrophy (MSA) according to Gilman's criteria; 2.Age >50 years; 3.Presence of orthostatic dizziness and orthostatic hypotension (defined as a drop in systolic blood pressure >=30 mmHg upon standing); 4.History of recurrent syncope; 5.Failure or intolerance to pharmacological treatment; 6.Patient and family members demonstrate adequate comprehension and communication abilities, voluntarily participate, and provide written informed consent.
Exclusion criteria
Exclusion criteria: 1.Cognitive dysfunction; 2.Supine hypertension (defined as supine blood pressure >160/90 mmHg after antihypertensive medication); 3.Secondary autonomic dysfunction caused by diabetes mellitus, spinal cord injury, amyloidosis, uremia, or other conditions; 4.Structural heart disease, including severe arrhythmia, valvular heart disease, myocardial infarction, or cardiac insufficiency; 5.Implanted cardiac devices; 6.Severe anxiety or depression; 7.Significant visual impairment; 8.Poor compliance or other conditions deemed unsuitable for trial participation by investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Orthostatic blood pressure and heart rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Walking Distance;Weekly Frequency of Syncope;Weekly Frequency of Presyncope;Variability of blood pressure;Heart Rate;Activities of Daily Living (ADL) Scale; | — |
Countries
China
Contacts
Public ContactLin Hua
Department of Neurology, Xuanwu Hospital, Capital Medical University
Outcome results
None listed