Pediatric humeral fracture
Conditions
Interventions
The Remimazolam group:Intravenous injection of Remimazolam 0.3 mg/kg
The saline group:Received an intravenous injection of an equivalent volume of saline
Sponsors
Ningbo No.6 Hospital
Eligibility
Sex/Gender
All
Age
2 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1.Age between 2 and 6 years; 2.ASA physical status classification I–II; 3.BMI < 28 kg/m^2; 4.Scheduled for elective internal fixation of humeral fracture; 5.Written informed consent signed by the legal guardian.
Exclusion criteria
Exclusion criteria: 1. Developmental delay, cognitive impairment, or sleep disorders; 2. Presence of severe congenital diseases, coagulation disorders, or immunological diseases; 3. Allergy to benzodiazepines and/or remimazolam or esketamine; 4. Upper respiratory tract infection or asthma; 5. Infection at the puncture site; 6. Use of other sedative or analgesic medications within the past week; 7. Inability to establish peripheral venous access.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED90 of esketamine for inhibiting movement responses during brachial plexus block puncture in pediatric patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in vital signs;Adverse reactions such as dizziness, nausea and vomiting, drowsiness, and delirium.; | — |
Countries
China
Contacts
Public ContactZhang Liangguang
Ningbo No.6 Hospital
Outcome results
None listed