Prolonged disorders
Conditions
Interventions
the stimulation of posterior parietal cortex:Transcranial direct current stimulation of the posterior parietal cortex target site in subjects
the stimulation of left dorsolateral prefrontal cortex:Transcranial direct current stimulation of left dorsolateral prefrontal cortex target site in subjects
the sham stimulation:Sham stimulation of left dorsolateral prefrontal cortex target site in subjects
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Cranial brain injury is the primary etiological factor, confirmed by cranial CT and/or MRI examination, accompanied by impaired consciousness, with the causative factors being traumatic, stroke-related, or hypoxic-ischemic. 2. Duration of impaired consciousness is more than 28 days. 3. The level of conscious impairment was assessed using the CRS-R scale as unresponsive wakefulness syndrome (UWS) or minimal consciousness state (MCS). 4. Vital signs meet the criteria for early rehabilitation intervention. 5. The patient's family would voluntarily provide informed consent and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients are in critical condition with unstable vital signs. 2.The patients have unstable intracranial conditions (active cerebral hemorrhage, secondary traumatic brain injury, severe hydrocephalus, etc.); 3.The patients have intracranial metal implants. 4.The patients have pacemakers. 5.The patients have intracranial tumors, infectious encephalopathy, or metabolic encephalopathy. 6.The patients have a recent onset of epilepsy. 7.Skin infection or damage is present at the site of cranial stimulation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coma recovery scale-revised; | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional connectivity strength of brain networks;Functional connectivity maps of brain networks;Brain network channel activation levels; | — |
Countries
China
Contacts
Public ContactYuhang Kong
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed