percutaneous nephrolithotomy
Conditions
Interventions
Ketamine experimental group (K group):K group anesthesia induction medication: ketamine injection (0.2-0.4mg/kg)+propofol (1.5-2.5mg/kg)+phenylsulfonylureate injection (0.2mg/kg), maintenance medicati
Sufentanil control group (C group):Group C anesthesia induction medication: sufentanil citrate injection (0.2-0.4ug/kg)+propofol (1.5-2.5mg/kg)+phenylsulfonylurea injection (0.2mg/kg), maintenance med
Sponsors
Huizhou First Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients who require percutaneous nephrolithotomy for stone removal; 2. Serious damage to major organs such as heart and lungs, and able to cooperate with various operations; 3. ASA grades I-III; 4. Patients aged between 20 and 70 years old; 5. Patient informed consent.
Exclusion criteria
Exclusion criteria: 1. Refusing to sign the informed consent form; 2. Severe allergy to anesthetic drugs; 3. Severe hypertension, diabetes and cardiovascular disease; 4. Patients with severe inflammation of other organs; 5. Individuals with severe drug or alcohol dependence, and a history of opioid abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Kidney Injury Molecule-1(kim-1);neutrophil gelatinase-associated lipocalin(NGAL);interleukin-6(IL-6);Tumor necrosis factor - a(TNF-a); | — |
Secondary
| Measure | Time frame |
|---|---|
| 15-item recovery quality rating scale;visual analogue scale score;RASS;blood pressure; | — |
Countries
China
Contacts
Public ContactYang Junta
Huizhou First Hospital
Outcome results
None listed