postoperative pain
Conditions
Interventions
Control group (Ctrl):All patients used the same anesthesia scheme, and the postoperative analgesia pump used different drug compatibility according to the grouping. The patients in the control group w
Experimental Group 1 (S1):The experimental group 1 was treated with empirical analgesic sufentanil at a dose of 1 µ g/kg, and non-opioid analgesic esmketamine at a dose of 2mg/kg. The antiemetic drug
Experimental Group 2 (S2):The experimental group 2 patients were treated with empirical analgesic sufentanil, dose 1 µ g/kg, non opioid analgesic esmketamine, dose 2mg/kg, and sedative dexmedetomidine
Sponsors
The First Affiliated Hospital of University of Science and Technology of China
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age>= 18 years old, gender unlimited. 2. Patients undergoing thoracoscopic surgery under general anesthesia. 3. The American Society of Anesthesiologists (ASA) classifies it as I-III levels. 4. Voluntary signing of informed consent.
Exclusion criteria
Exclusion criteria: 1. The surgical method has been changed from thoracoscopy to open chest surgery for patients. 2. Unplanned secondary surgery patients. 3. Patients transferred to ICU after surgery. 4. BMI>= 30kg/?. 5. Individuals known to be allergic to the active ingredients or excipients of ketamine injection. 6. Combining elevated intracranial pressure with central nervous system injury or disease. 7. Patients with a history of severe mental disorders (excluding depression). 8. Patients with heart dysfunction, a history of myocardial infarction, and tachycardia. 9. Severe cardiac conduction block (e.g., third-degree atrioventricular block). 10. Patients with severe liver and kidney dysfunction. 11. Refuse to attend the patients. 12. Withdrawing midway.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Pain;Postoperative recovery quality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of times of remedial analgesia;Opioid consumption within 48 hours;Anxiety and depression;nausea and vomiting;Dizziness, hallucinations, nightmares;Postoperative hospitalization days;Incidence of chronic pain one month after surgery; | — |
Countries
China
Contacts
Public ContactMingxu Zhao
The First Affiliated Hospital of University of Science and Technology of China
Outcome results
None listed