Anesthesia depth and noxious stimuli
Conditions
Interventions
Sevoflurane observation group:None
Propofol Observation group:None
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1.Age: 6 months to 18 years (inclusive but exclusive), undergoing elective non-cardiac surgery under general anesthesia; 2.ASA I-III grade; 3. The expected anesthesia time (defined as the period from anesthesia induction to the discontinuation of the anesthetic drug) is greater than 30 minutes; 4. Obtain permission from parents or guardians (sign an informed consent form).
Exclusion criteria
Exclusion criteria: 1. Born with congenital malformations or other diseases that may affect brain development (such as neonatal hypoxic-ischemic encephalopathy, genetic diseases, chromosomal diseases, etc.); 2. Suffering from neurological, mental disorders or severe cardiovascular system diseases (such as complex congenital heart disease, cyanotic congenital heart disease); 3. The area for electroencephalogram (EEG) monitoring conflicts with the area for surgical disinfection. 4. Long-term treatment with sedatives (such as propofol, midazolam, dexmedetomidine, ketamine, etc.), opioids (such as morphine, fentanyl, etc.) or antipsychotic drugs; 5. Known to be allergic to or have adverse reactions to electroencephalogram or electrocardiogram electrode adhesives; 6. Children who are not suitable for inhalation anesthesia (such as those with a family history of malignant high fever or those requiring intraoperative neurological function monitoring, etc.). 7. Allergic to drugs, sensors, etc. used in the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Predictive models of anesthesia depth for children; | — |
Secondary
| Measure | Time frame |
|---|---|
| EEG features of noxious stimuli;Incidence of postoperative delirium in children and related EEG features; | — |
Countries
China
Contacts
Public ContactYuyi Zhao
West China Hospital, Sichuan University
Outcome results
None listed