Sleep Disorders
Conditions
Interventions
Pure Insomnia Group:Diagnosis of insomnia, SAS score = 50, and GAD-7 score >= 10
Insomnia with Medication Withdrawal Group:Diagnosis of insomnia, diagnosis of sedative use disorder, and presence of withdrawal symptoms
Sponsors
The First People's Hospital of Zunyi
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age 18 to 75; 2.Sex-matched (male:female ˜ 1:1)?; 3.Signed the informed consent form and completed the baseline assessment (including polysomnography/PSG, neurocognitive testing, and biological sample collection).
Exclusion criteria
Exclusion criteria: 1.Major organic diseases:?? Cardiac insufficiency (NYHA class III or higher); severe hepatic or renal dysfunction (ALT/AST > 3x upper limit of normal, eGFR 15); history of alcohol or substance abuse (AUDIT score > 8); 3.Confounding factors of other sleep disorders:?? Diagnosed central disorders of hypersomnolence (e.g., narcolepsy); pregnant or lactating women (due to potential hormonal interference with sleep architecture); 4.Technical and data collection limitations:?? Implanted electronic devices (e.g., pacemakers, which may interfere with PSG signals); cognitive impairment preventing cooperation with testing; contraindications for biological sample collection (e.g., coagulation disorders);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Melatonin;Cortisol;New-onset sleep disorder;Disease progression;Treatment response event (Objective Response Rate); | — |
Secondary
| Measure | Time frame |
|---|---|
| PSQI;Orexin;Actigraphy / Activity Tracker;AIS;Sleep Diary; | — |
Countries
China
Contacts
Public ContactZhang jing
The First People's Hospital of Zunyi
Outcome results
None listed