Ureteral calculi
Conditions
Interventions
Experimental group:Induction of anesthesia: a loading dose of 1.5 mg oliceridine (bolus time >1 minute)
Sponsors
Mengcheng County First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years old; 2. ASA classification I-II; 3.BMI18.5-28 4. Patients scheduled for elective holmium laser lithotripsy via ureteroscopy; 5.The start time of surgery is all before 12:00. 6. Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Known allergy to oxycodone, sufentanil, or other opioids; 2. Severe dysfunction of vital organs such as heart, liver, or kidneys; 3. Severe respiratory diseases (e.g., COPD GOLD III-IV, uncontrolled OSA); 4. Long-term use of opioids (>3 months), history of drug abuse, or use of potent opioids within 24 hours before surgery; 5. Severe sleep disorders or diagnosed sleep apnea syndrome (untreated) before surgery; 6. Mental illness that prevents cooperation with assessment; 7. Pregnant or breastfeeding women; 8. Investigators deem the individual unsuitable for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subjective sleep quality (sleep diary) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient satisfaction;Hospitalization period;Postoperative pain;Postoperative nausea and vomiting;Respiratory depression;The incidence of coughing reflex during anesthesia induction;Intraoperative hemodynamic stability;The time of the first postoperative exhaust/defecation;Self-Rating Anxiety?Scale;Self-rating depression scale;Heart rate variability ;Pittsburgh Sleep Quality Index;S100 Calcium Binding Protein B;Melatonin;Neuron-specific enolase(NSE);Iridin;Brain-derived neurotrophic factor;Interleukin-6; | — |
Countries
People's Republic of China
Contacts
Public ContactZhangMeng
Anhui Province Mengcheng County No.1 People's Hospital
Outcome results
None listed